So I'm on Win 10, in a corporate environment. My PC is a beast, internet is fast as it can be, but a few times a week the Spotify Desktop app and most browsers will start having stuttering, maybe every 10 seconds, or sometimes less frequent, but enough to be noticable and ruin the listening experience.
There isn't any clear indication as to the cause, and nothing makes it go away. The only way I can listen without any stuttering is to use the Microsoft Edge browser, but that player randomly stops outputting any audio so I'm constantly fighting the buggy web player instead. I can stream from other services without any sound quality issues.
A heads up for everyone using a Creative Sound Blaster card and experiencing issues; Creative released new drivers a couple of days ago (yup, 2019 driver update for 10yr old cards) that has fixed all issues I was having with Spotify in Windows 10. With a bit of luck, these new drivers will solve the issue for others too! So check if there are updated drivers for your card :) For reference, I use a Sound Blaster X-Fi Titanium Fatal1ty Professional card.
If still unsuccessful, I figured out a bit more of an advanced workaround using ASIO drivers that I could write up here.