When the Spotify app is in focus keep the screen on and prevent it from locking. Just like in PowerAmp, this should be an optional setting.
It's really annoying to have to unlock the phone to skip tracks, or see the name of the current song or artist, especially when driving.
Updated on 2019-09-19
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With the release of Car View, your screen will always remain on when driving - or when turning it on manually in the settings.
When you connect your phone to your car’s Bluetooth, car view automatically turns on. You see larger, driver-friendly icons in the Now Playing view, and you can quickly change what plays with Choose Music at the bottom of the screen.
For more info about listening to Spotify in the car, check out this article.