I'm using "Ctrl + Alt + x" and "Ctrl + Alt + shift + x" to control the volume in my system. I have noticed that Spotify is mistaken "Ctrl + Alt + x" for "Ctrl + x", which will cut out songs from the current playlist. Its very annoying when tracks are removed from playlist by changing volume.
Installed Spotify using snappy in Ubuntu 16.04. Probably be a problem in Windows and OSx as well.
Also, I find it quite annoying that backspace is removing tracks from the playlist. A decent keyboard has a delete key ;)
Maybe Spotify can add a setting that disable keyboard shortcuts. That would solve all my issues.