When playing Spotify through a Google home I was using the Spotify Android app to control the music. I repeatedly pressed the play/pause button and found that it will continuously repeat the input seemingly infinitely, but certainly many times more than I pressed the play/pause button.
The only way I've found to escape this play/pause loop is to change the song using the Google voice commands. The Spotify app becomes somewhat unresponsive and changing song doesn't work.
Hope this helps someone