This used to be the case, but since the last few versions of Spotify Desktop re-opening the app does not automatically focus the keyboard on the Play/Pause button.
How to reproduce:
When you click anywhere in the Spotify app, then the space bar will Play/Pause as usual.
This behavior makes it inconvenient to quickly hide Spotify when not needed, and go back to play/pause (without having to use the mouse) when desired.
Hope this can be fixed in a (near) future version!
Solved! Go to Solution.