Spotify gets unresponsive -> You close it. Try to reopen it and you get a message box with "The Application is not responding". Only works again if you go to task manager and kill any process that's related to Spotify.
This has been reported before by loads of people but the topic here was randomly closed without a solution in a very tone deaf way: https://community.spotify.com/t5/Desktop-Windows/The-Spotify-application-is-not-responding/m-p/54134...
Most people report the exact same thing and somehow it's marked as "too general".